ENDOGLIM MP1 Tablet 15's

INTRODUCTION ABOUT ENDOGLIM MP1 TABLET

ENDOGLIM MP1 TABLET is used to manage type II diabetes mellitus when diet, exercise and management with single agent does not result in adequate sugar control. It is a combination of Glimepiride, Metformin and Pioglitazone which belongs to the group of medicines called Antidiabetic agents.

Before taking ENDOGLIM MP1 TABLET, inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any eye problems, hormonal imbalance, alcoholism, or if you are malnourished, starved, on an irregular diet as a precaution. It is strictly not recommended for use in patients with type I diabetes mellitus, bladder cancer, severe heart failure or lactic acidosis.

Along with the management, follow the diet and lifestyle changes advised by your doctor to achieve better results. Avoid smoking and consumption of alcohol while taking the medicine as it may aggravate the existing condition. The most common side effects are low blood sugar levels, nausea, stomach upset, constipation, sore throat, muscle pain, headache, dizziness and weight gain. Consult your doctor if any of these side effect worsens.

USES OF ENDOGLIM MP1 TABLET

• Used to manage type II diabetes mellitus

HOW ENDOGLIM MP1 TABLET WORKS

ENDOGLIM MP1 TABLET stimulates the pancreas to secrete more insulin (a hormone involved in glucose metabolism). It also makes our body more sensitive to insulin which helps in digesting the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels. Additionally, it can also reduce the glucose produced by the liver and reduces its absorption in the body.

DIRECTIONS FOR USE

• Take ENDOGLIM MP1 TABLET preferably after meals or as advised by your physician
• Swallow the medicine with a glass of water. Do not crush or chew the medicine
• Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
• Do not stop taking ENDOGLIM MP1 TABLET unless your doctor advice you to stop

SIDE EFFECTS OF ENDOGLIM MP1 TABLET

Common side effects of ENDOGLIM MP1 TABLET:

• hypoglycemia (low blood sugar levels)
• diarrhea, stomach pain, loss of appetite, flatulence
• changes in taste, metallic taste
• joint pain, back pain, muscle pain

Stop taking ENDOGLIM MP1 TABLET and contact your doctor immediately if you experience any of the following side effects:

• signs of lactic acidosis (cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)
• symptoms of heart failure (such as unusual shortness of breath or trouble in breathing, rapid increase in weight or localised swelling (oedema), especially in the ankles or legs, unusual tiredness)
• signs and symptoms of bladder cancer (blood in your urine, pain while urinating or urgent need to pee)
• increased risk of fractures (especially in the bones of hand, upper arm, or foot in women)
• blurred vision due to swelling at the back of the eye or worsening of existing blurred vision
• serious allergic reaction (hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
• signs of liver problems (nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin or the whites of the eyes)

WARNING & PRECAUTIONS

PREGNANCY

Consult your doctor

There are no adequate human data to determine the safety of ENDOGLIM MP1 TABLET during pregnancy.

BREASTFEEDING

Consult your doctor

It is not known if ENDOGLIM MP1 TABLET passes into human milk and if it can harm your baby. Talk to your doctor about the best way to control your blood glucose levels while breastfeeding.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or operate any heavy tools or machines if your ability is affected by ENDOGLIM MP1 TABLET.

ALCOHOL

Consult your doctor

Avoid consumption of alcohol while taking ENDOGLIM MP1 TABLET as it may increase the risk of unwanted side effects.

KIDNEY

Consult your doctor

ENDOGLIM MP1 TABLET is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems.

LIVER

Consult your doctor

ENDOGLIM MP1 TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other liver problems.

ALLERGY

Contraindicated

Do not take ENDOGLIM MP1 TABLET if you are allergic to Glimepiride, Metformin, Pioglitazone or to any other ingredients of this medicine.

HEART DISEASE

Consult your doctor

ENDOGLIM MP1 TABLET is not recommended for use in patients with severe heart problems (such as heart failure). It should be used with caution in patients with other heart problems.  

USE IN PEDIATRICS

Contraindicated

ENDOGLIM MP1 TABLET is not recommended for use in children and in adolescents (aged below 18 years).  

USE IN GERIATRICS

Use with Caution

ENDOGLIM MP1 TABLET should be used with caution in elderly patients (aged above 65 years).

INTERACTIONS

A. Drug-Drug Interactions:

Before taking ENDOGLIM MP1 TABLET, inform your doctor if you are taking any of the following medicines:

• Antidiabetics (Ex. teneligliptin, rosiglitazone, insulin, gliclazide)
• Non-steroidal anti-inflammatory agents (Ex. aspirin, ibuprofen, celecoxib, phenylbutazone, azopropazone, oxyphenbutazone)
• Antibiotics (Ex. amikacin, nitrofurantoin, sulfamethoxazole, tetracyclines, chloramphenicol, ciprofloxacin, clarithromycin, Trimethoprim)
• Antifungals (Ex. fluconazole, miconazole, isuvaconazole)
• Anticoagulants (Ex. warfarin)
• Hormone replacement therapy (Ex. testosterone)
• Antidepressants (Ex. moclobemide, isocarboxazid, phenelzine, tranylcypromine, fluoxetine, chlorpromazine, prochlorperazine, lithium)
• Anti-lipidemic agents (Ex. fenofibrate, nicotinic acid, colesevelam)
• Antihypertensives (Ex. enalapril, lisinopril, ramipril, atenolol, propranolol, telmisartan, olmesartan, clonidine, guanethidine and reserpine)
• Anti-arrhythmic agent (Ex. Disopyramide)
• Anti-gout agents (Ex. allopurinol, probenecid, sulfinpyrazone)
• Anti-cancer agents (Ex. cyclophosphamide, ifosfamide, trofosfamide, vandetanib, crizotinib and olaparib)
• Hemorrheologic agents (Ex. Pentoxifylline)
• Enzyme inhibitor (Ex. tritoqualine)
• Alpha blockers (Ex. prazosin, doxazosin)
• Hormonal replacement therapy (Ex. estradiol)
• Thiazide diuretics (Ex. hydrochlorothiazide)
• Hormones (Ex. Levothyroxine)
• Corticosteroids (Ex. prednisolone, betamethasone)
• Bronchodilators (Ex. salbutamol, terbutaline)
• Alpha- and beta-adrenergic agonists (Ex. Adrenaline)
• Laxatives (Ex. lactulose, liquid paraffin)
• Anticonvulsants (Ex. phenytoin, Fenfluramine)
• Barbiturates (Ex. phenobarbital)
• Carbonic anhydrase inhibitor (Ex. acetazolamide)
• H2 blockers (Ex. Cimetidine)
• Anti-TB agents (Ex. Rifampicin)
• HIV integrase inhibitors (Ex. Dolutegravir)
• Anti-anginal (Ex. Ranolazine)

Overdosage:

If you or anyone else accidentally took more ENDOGLIM MP1 TABLET, you may experience the signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, fast heartbeat and confusion). To manage this, consume any sugary food immediately. If the symptom did not improve or worsens contact your doctor immediately. Other symptoms of overdosage might include vomiting, stomach pain with muscle cramps, feeling generally unwell with severe tiredness and difficulty in breathing.

SYNOPSIS

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