DAPARYL M 10/1000 Tablet 10's

INTRODUCTION ABOUT DAPARYL M 10/1000 TABLET

DAPARYL M 10/1000 TABLET is used to manage type-2 diabetes mellitus along with diet and exercise when diabetes cannot be controlled with other medicines. It is also used in combination with insulin or GLP-1 receptor agonist like liraglutide. It is a combination of Dapagliflozin and Metformin which belongs to the group of medicines called Antidiabetics. DAPARYL M 10/1000 TABLET helps to lowers blood glucose levels, where Dapagliflozin works by removing excess sugar from the body in the form of urine and Metformin works by inhibiting glucose production in the liver.

Prior to the management, your doctor may want you to take several blood tests to understand your existing kidney condition. Avoid consumption of alcohol while taking DAPARYL M 10/1000 TABLET as it may increase the risk of lactic acidosis. DAPARYL M 10/1000 TABLET is not recommended for use in patients with liver disease, moderate to severe kidney disease, recent heart attack or acute myocardial infarction, heart failure, septicemia or severe infection, diabetic ketoacidosis, hypoxemia or uncontrolled diabetes. Contact your doctor before taking the medicine.

DAPARYL M 10/1000 TABLET is not recommended for use in second and third trimester of pregnancy unless considered clearly necessary. DAPARYL M 10/1000 TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. DAPARYL M 10/1000 TABLET is not recommended for use in children and adolescents under 18 years of age. DAPARYL M 10/1000 TABLET should be used with caution in elderly patients (aged 65 years or above). The most common side effects of this medicine are diarrhea, stomach pain and loss of appetite. Contact your physician if any of the above side effects worsen or persists for a longer duration.

USES OF DAPARYL M 10/1000 TABLET

• Used in the management of type-2 diabetes mellitus

HOW DAPARYL M 10/1000 TABLET WORKS

DAPARYL M 10/1000 TABLET helps to lowers blood glucose levels, where Dapagliflozin works by removing excess sugar from the body in the form of urine and Metformin works by inhibiting glucose production in the liver.

DIRECTIONS FOR USE

• Take this medicine as advised by your physician
• Swallow this medicine as whole with a glass of water and do not crush or chew the medicine
• Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition

SIDE EFFECTS OF DAPARYL M 10/1000 TABLET

Common Side Effects of DAPARYL M 10/1000 TABLET

• diarrhoea
• stomach pain
• loss of appetite
• genital infection (irritation, itching, unusual discharge, or odour)
• back pain
• increased urination
• decrease in creatinine clearance
• changes in taste
• constipation

Stop taking DAPARYL M 10/1000 TABLET and contact your physician immediately if you experience any of the following side effects:

• nausea, vomiting, stomach pain, muscle cramps, feeling of not being well with severe tiredness, body pain, increasing somnolence, difficulty in breathing, dizziness, light headedness, reduced body temperature, heartbeat, and low blood pressure (symptoms of lactic acidosis)
• dehydration, nausea, vomiting, abdominal pain, excessive thirst, generalised weakness, rapid weight loss, fast and deep breathing, confusion, unusual sleepiness or tiredness, fruity smell breath, a sweet or metallic taste in mouth, different odour to your urine or sweat (signs and symptoms of diabetic ketoacidosis)
• fever, chills, burning sensation while passing urine, back pain, or blood in urine (signs of urinary tract infection)
• weakness, shaking, sweating, drowsiness, dizziness, feeling very anxious, fast heartbeat, hunger, headache, change in vision, change in mood or confusion, and irritability (signs of low blood sugar)

WARNING & PRECAUTIONS

PREGNANCY

Risky

DAPARYL M 10/1000 TABLET should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.  

BREASTFEEDING

Consult your doctor

It is not known whether DAPARYL M 10/1000 TABLET pass through the breast milk, contact your doctor before taking the medicine.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or operate any machines if you experience symptoms of hypoglycaemia such as weakness, dizziness, increased sweating, fast heartbeat, change in vision, difficulty in concentration, weakness, sleepiness, light-headedness after taking DAPARYL M 10/1000 TABLET.

ALCOHOL

Consult your doctor

Avoid consumption of alcohol while taking DAPARYL M 10/1000 TABLET as it increases the risk of lactic acidosis.

KIDNEY

Consult your doctor

DAPARYL M 10/1000 TABLET is not recommended for use in patients with moderate to severe kidney disease. It should be used with caution in patients with acute kidney injury.

LIVER

Use with Caution

DAPARYL M 10/1000 TABLET should be used with caution in patients with liver disease.

ALLERGY

Contraindicated

Do not take DAPARYL M 10/1000 TABLET if you are allergic to Dapagliflozin, Metformin or to any other ingredients of this medicine.

HEART DISEASE

Consult your doctor

DAPARYL M 10/1000 TABLET is not recommended for use in patients with recent heart attack or acute myocardial infarction, heart failure, cardiovascular shock. It should be used with caution in patients with hypotension.

USE IN PEDIATRICS

Consult your doctor

It is not known whether DAPARYL M 10/1000 TABLET is safe and effective in children and adolescents below 18 years of age.

USE IN GERIATRICS

Use with Caution

DAPARYL M 10/1000 TABLET should be used with caution in elderly patients (aged above 65 years).

INTERACTIONS

A. Drug-Drug interactions:

Before taking DAPARYL M 10/1000 TABLET inform your doctor if you are taking any of the following medicine:

• Antidiabetics (Ex. glyburide, metformin, pioglitazone, sitagliptin, glimepiride, voglibose and insulin)
• Diuretics (Ex. furosemide, nifedipine, propranolol, enalapril, hydrochlorothiazide, bumetanide, valsartan, digoxin, ranolazine)
• Anticoagulants (Ex. warfarin)
• Antilipidemic agents (Ex. simvastatin)
• Anti-TB agents (Ex. isoniazid, rifampin)
• NSAID’s (Ex. ibuprofen, mefenamic acid)
• H2 blockers (Ex. cimetidine)
• Anticonvulsants (Ex. phenytoin or phenobarbital)
• Anti-viral agents (Ex. ritonavir, dolutegravir)
• Short-acting beta-2 adrenergic agonist (Ex. salbutamol)
• kinase inhibitors (Ex. vandetanib)
• carbonic anhydrase inhibitors (Ex. acetazolamide, zonisamide, or dichlorphenamide)
• Corticosteroids (Ex. betamethasone, dexamethasone)
• Ant-psychotics (Ex. fluphenazine)
• Hormones (Ex. levothyroxine)
• Oral contraceptives (Ex. levonorgestrel)  
• Vitamin supplements (Ex. nicotinic acid)

Overdosage:

If you or anyone else accidentally took too much of this medicine, consult your doctor immediately. Symptoms of overdose are hypoglycaemia and lactic acidosis.

SYNOPSIS

FAQs ABOUT DAPARYL M 10/1000 TABLET

Q: Can I take alcohol while taking DAPARYL M 10/1000 TABLET?

A: No. Avoid consumption of alcohol while taking DAPARYL M 10/1000 TABLET as it may increase the risk of lactic acidosis.

Q: How does DAPARYL M 10/1000 TABLET work?

A: DAPARYL M 10/1000 TABLET contains two antidiabetic medicines Metformin and Dapagliflozin which lowers the blood sugar levels in type 2 diabetes mellitus by eliminating excess sugars through urine and also by increasing the activity of insulin.

Q: Can I use DAPARYL M 10/1000 TABLET with other diabetic medications?

A: Your doctor may advise DAPARYL M 10/1000 TABLET with or without other medications to control your blood sugar levels. However, it is advised to maintain a proper diet and exercise to achieve the controlled blood sugar levels while using this medicine with or without other antidiabetic medications.

Q: Does DAPARYL M 10/1000 TABLET cause low blood sugar?

A: Yes. DAPARYL M 10/1000 TABLET may cause low blood sugar. Stop taking DAPARYL M 10/1000 TABLET and contact your doctor if you experience any unusual symptoms like weakness, shaking, sweating, drowsiness, dizziness, feeling very anxious, fast heartbeat, hunger, headache, change in vision, change in mood or confusion, and irritability. Consult your doctor for advice.