DAPANOVA S 5/50 Tablet 10's

INTRODUCTION ABOUT DAPANOVA S 5/50 TABLET

DAPANOVA S 5/50 TABLET is used to manage type II diabetes mellitus which is inadequately controlled on metformin monotherapy. It is a combination of Dapagliflozin and Sitagliptin which belongs to the group of medicines called Antidiabetic agents. It effectively controls blood sugar levels where dapagliflozin inhibits SGLT2, increasing urinary glucose excretion and reducing blood levels of glucose and Sitagliptin inhibits DPP-4, increases glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), resulting in increased insulin synthesis and decreased glucagon release.

DAPANOVA S 5/50 TABLET is not recommended for use in patients having severe kidney problems or those on dialysis. Before taking the medicine, inform your doctor if you have inflammation of the pancreas, gallstones, alcohol dependence, or very high levels of triglycerides in the blood or any heart, kidney or liver problems. It should be used in pregnant women only if considered clearly necessary. It should be used with caution in breastfeeding women. Safety and effectiveness of DAPANOVA S 5/50 TABLET in children and adolescents (under 18 years of age) have not been established.

It is important to stay on the diet and exercise recommended by your doctor while taking DAPANOVA S 5/50 TABLET as it can help the body use its blood sugar better. The most common side effects are headache, flatulence and constipation. Consult your doctor if any of the side effects worsen or persist for a longer period of time.

USES OF DAPANOVA S 5/50 TABLET

• Used to manage type II diabetes mellitus (which is inadequately controlled on metformin monotherapy)

HOW DAPANOVA S 5/50 TABLET WORKS

DAPANOVA S 5/50 TABLET effectively controls blood sugar levels where Dapagliflozin inhibits SGLT2, increasing urinary glucose excretion and reducing blood levels of glucose and Sitagliptin inhibits DPP-4, increases glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), resulting in increased insulin synthesis and decreased glucagon release.

DIRECTIONS FOR USE

• Take DAPANOVA S 5/50 TABLET as advised by your physician
• Swallow the medicine with a glass of water. Do not crush or chew the medicine
• It can be taken with or without food
• Your doctor will decide the correct dose and duration of DAPANOVA S 5/50 TABLET therapy depending on your age, body weight and disease condition.

SIDE EFFECTS OF DAPANOVA S 5/50 TABLET

Common Side Effects of DAPANOVA S 5/50 TABLET:

• flatulence, constipation, stomach pain, diarrhea
• swelling of hands or legs
• headache, dizziness
• stuffy or runny nose, sore throat
• passing urine more often
• dry mouth

Stop taking DAPANOVA S 5/50 TABLET and contact your physician immediately if you experience any of the following side effects:

• inflamed pancreas (severe and persistent stomach pain that might reach through the back with or without nausea and vomiting)
• serious allergic reaction (rash, hives, blisters on the skin or peeling skin and swelling of the lips, tongue, face and throat that may cause difficulty in breathing or swallowing)
• diabetic ketoacidosis (increased levels of ketone bodies in urine or blood, nausea or vomiting, stomach ache, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to breathe, a sweet or metallic taste in the mouth or a different odor in urine or sweat, rapid weight loss)
• urinary tract infection (fever, chills, burning sensation when passing urine, pain in the back or side, blood in urine)
• low blood sugar levels (shaking, sweating, feeling very anxious, fast heartbeat, feeling hungry, headache, change in vision, and a change in mood or feeling confused)

WARNING & PRECAUTIONS

PREGNANCY

Consult your doctor

If you are pregnant or think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.

BREASTFEEDING

Consult your doctor

It is not known if this medicine passes into breast milk. You should not take this medicine if you are breast-feeding or plan to breast-feed.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or operate any machines if you feel dizzy or sleepy after taking DAPANOVA S 5/50 TABLET.

ALCOHOL

Consult your doctor

Avoid consumption of alcohol while taking DAPANOVA S 5/50 TABLET as it may increase the chance of diabetic ketoacidosis.  

KIDNEY

Use with Caution

DAPANOVA S 5/50 TABLET can be used with caution in patients who had or have any kidney problems.

LIVER

Use with Caution

DAPANOVA S 5/50 TABLET can be used with caution in patients with severe liver impairment.

ALLERGY

Contraindicated

Do not take DAPANOVA S 5/50 TABLET if you are allergic to Dapagliflozin, Sitagliptin or any other ingredients of this medicine.

HEART DISEASE

Use with Caution

DAPANOVA S 5/50 TABLET can be used with caution in patients who have heart failure.

USE IN PEDIATRICS

Consult your doctor

Safety and effectiveness of DAPANOVA S 5/50 TABLET in children and adolescents (under 18 years of age) have not been established.  

USE IN GERIATRICS

Consult your doctor

No dose adjustment is required for elderly patients.

INTERACTIONS

A. Drug-Drug interactions:

Before taking DAPANOVA S 5/50 TABLET, inform your doctor if you are taking any of the following medicines:

• Anti-fungal (Ex. ketoconazole, itraconazole)
• Anti-viral agents (Ex. Ritonavir)
• Antibiotics (Ex. Clarithromycin)
• Immunosuppressants (Ex. Ciclosporin)
• Cardiac glycosides (Ex. Digoxin)
• Diuretics (Ex. hydrochlorothiazide, furosemide)
• Anti-diabetics (Ex. metformin, insulin, glimepiride)

Overdosage:

If you or anyone else accidentally takes too much of DAPANOVA S 5/50 TABLET, consult your doctor or visit a nearby hospital immediately.

SYNOPSIS

FAQs ABOUT DAPANOVA S 5/50 TABLET

Q: What is DAPANOVA S 5/50 TABLET and why it is prescribed?

A: DAPANOVA S 5/50 TABLET is a combination of Dapagliflozin and Sitagliptin which belongs to the group of medicines called Antidiabetic agents. It is used to manage type II diabetes mellitus which is inadequately controlled on metformin monotherapy.

Q: Does DAPANOVA S 5/50 TABLET cause weight loss?

A: Yes, DAPANOVA S 5/50 TABLET may cause weight loss in some individuals. To avoid weight loss, follow a healthy diet and regular physical activity as advised by your physician.

Q: Can DAPANOVA S 5/50 TABLET be taken along with insulin?

A: Taking DAPANOVA S 5/50 TABLET along with insulin might increase the chance of hypoglycemia.

Q: How does DAPANOVA S 5/50 TABLET work?

A: DAPANOVA S 5/50 TABLET effectively controls blood sugar levels where dapagliflozin inhibits SGLT2, increasing urinary glucose excretion and reducing blood levels of glucose and Sitagliptin inhibits DPP-4, increases glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), resulting in increased insulin synthesis and decreased glucagon release.

Q: Is DAPANOVA S 5/50 TABLET safe to use in patients with kidney problems?

A: DAPANOVA S 5/50 TABLET can be used with caution in patients who had or have any kidney problems. Your doctor may monitor your kidney function test before and during management with this medicine to manage the risk of any unusual effects.