DEBISTAL GM 2 Tablet 10's

INTRODUCTION ABOUT DEBISTAL GM 2 TABLET

DEBISTAL GM 2 TABLET is used to manage type II diabetes mellitus when diet, exercise and management with single agent does not result in adequate sugar control. It is a combination of Glimepiride, Metformin and Pioglitazone which belongs to the group of medicines called Antidiabetic agents.

Before taking DEBISTAL GM 2 TABLET, inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any eye problems, hormonal imbalance, alcoholism, or if you are malnourished, starved, on an irregular diet as a precaution. It is strictly not recommended for use in patients with type I diabetes mellitus, bladder cancer, severe heart failure or lactic acidosis.

Along with the management, follow the diet and lifestyle changes advised by your doctor to achieve better results. Avoid smoking and consumption of alcohol while taking the medicine as it may aggravate the existing condition. The most common side effects are low blood sugar levels, nausea, stomach upset, constipation, sore throat, muscle pain, headache, dizziness and weight gain. Consult your doctor if any of these side effect worsens.

USES OF DEBISTAL GM 2 TABLET

• Used to manage type II diabetes mellitus

HOW DEBISTAL GM 2 TABLET WORKS

DEBISTAL GM 2 TABLET stimulates the pancreas to secrete more insulin (a hormone involved in glucose metabolism). It also makes our body more sensitive to insulin which helps in digesting the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels. Additionally, it can also reduce the glucose produced by the liver and reduces its absorption in the body.

DIRECTIONS FOR USE

• Take DEBISTAL GM 2 TABLET preferably after meals or as advised by your physician
• Swallow the medicine with a glass of water. Do not crush or chew the medicine
• Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
• Do not stop taking DEBISTAL GM 2 TABLET unless your doctor advice you to stop

SIDE EFFECTS OF DEBISTAL GM 2 TABLET

Common side effects of DEBISTAL GM 2 TABLET:

• hypoglycemia (low blood sugar levels)
• diarrhea, stomach pain, loss of appetite, flatulence
• changes in taste, metallic taste
• joint pain, back pain, muscle pain

Stop taking DEBISTAL GM 2 TABLET and contact your doctor immediately if you experience any of the following side effects:

• signs of lactic acidosis (cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)
• symptoms of heart failure (such as unusual shortness of breath or trouble in breathing, rapid increase in weight or localised swelling (oedema), especially in the ankles or legs, unusual tiredness)
• signs and symptoms of bladder cancer (blood in your urine, pain while urinating or urgent need to pee)
• increased risk of fractures (especially in the bones of hand, upper arm, or foot in women)
• blurred vision due to swelling at the back of the eye or worsening of existing blurred vision
• serious allergic reaction (hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
• signs of liver problems (nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin or the whites of the eyes)

WARNING & PRECAUTIONS

PREGNANCY

Consult your doctor

There are no adequate human data to determine the safety of DEBISTAL GM 2 TABLET during pregnancy.

BREASTFEEDING

Consult your doctor

It is not known if DEBISTAL GM 2 TABLET passes into human milk and if it can harm your baby. Talk to your doctor about the best way to control your blood glucose levels while breastfeeding.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or operate any heavy tools or machines if your ability is affected by DEBISTAL GM 2 TABLET.

ALCOHOL

Consult your doctor

Avoid consumption of alcohol while taking DEBISTAL GM 2 TABLET as it may increase the risk of unwanted side effects.

KIDNEY

Consult your doctor

DEBISTAL GM 2 TABLET is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems.

LIVER

Consult your doctor

DEBISTAL GM 2 TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other liver problems.

ALLERGY

Contraindicated

Do not take DEBISTAL GM 2 TABLET if you are allergic to Glimepiride, Metformin, Pioglitazone or to any other ingredients of this medicine.

HEART DISEASE

Consult your doctor

DEBISTAL GM 2 TABLET is not recommended for use in patients with severe heart problems (such as heart failure). It should be used with caution in patients with other heart problems.  

USE IN PEDIATRICS

Contraindicated

DEBISTAL GM 2 TABLET is not recommended for use in children and in adolescents (aged below 18 years).  

USE IN GERIATRICS

Use with Caution

DEBISTAL GM 2 TABLET should be used with caution in elderly patients (aged above 65 years).

INTERACTIONS

A. Drug-Drug Interactions:

Before taking DEBISTAL GM 2 TABLET, inform your doctor if you are taking any of the following medicines:

• Antidiabetics (Ex. teneligliptin, rosiglitazone, insulin, gliclazide)
• Non-steroidal anti-inflammatory agents (Ex. aspirin, ibuprofen, celecoxib, phenylbutazone, azopropazone, oxyphenbutazone)
• Antibiotics (Ex. amikacin, nitrofurantoin, sulfamethoxazole, tetracyclines, chloramphenicol, ciprofloxacin, clarithromycin, Trimethoprim)
• Antifungals (Ex. fluconazole, miconazole, isuvaconazole)
• Anticoagulants (Ex. warfarin)
• Hormone replacement therapy (Ex. testosterone)
• Antidepressants (Ex. moclobemide, isocarboxazid, phenelzine, tranylcypromine, fluoxetine, chlorpromazine, prochlorperazine, lithium)
• Anti-lipidemic agents (Ex. fenofibrate, nicotinic acid, colesevelam)
• Antihypertensives (Ex. enalapril, lisinopril, ramipril, atenolol, propranolol, telmisartan, olmesartan, clonidine, guanethidine and reserpine)
• Anti-arrhythmic agent (Ex. Disopyramide)
• Anti-gout agents (Ex. allopurinol, probenecid, sulfinpyrazone)
• Anti-cancer agents (Ex. cyclophosphamide, ifosfamide, trofosfamide, vandetanib, crizotinib and olaparib)
• Hemorrheologic agents (Ex. Pentoxifylline)
• Enzyme inhibitor (Ex. tritoqualine)
• Alpha blockers (Ex. prazosin, doxazosin)
• Hormonal replacement therapy (Ex. estradiol)
• Thiazide diuretics (Ex. hydrochlorothiazide)
• Hormones (Ex. Levothyroxine)
• Corticosteroids (Ex. prednisolone, betamethasone)
• Bronchodilators (Ex. salbutamol, terbutaline)
• Alpha- and beta-adrenergic agonists (Ex. Adrenaline)
• Laxatives (Ex. lactulose, liquid paraffin)
• Anticonvulsants (Ex. phenytoin, Fenfluramine)
• Barbiturates (Ex. phenobarbital)
• Carbonic anhydrase inhibitor (Ex. acetazolamide)
• H2 blockers (Ex. Cimetidine)
• Anti-TB agents (Ex. Rifampicin)
• HIV integrase inhibitors (Ex. Dolutegravir)
• Anti-anginal (Ex. Ranolazine)

Overdosage:

If you or anyone else accidentally took more DEBISTAL GM 2 TABLET, you may experience the signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, fast heartbeat and confusion). To manage this, consume any sugary food immediately. If the symptom did not improve or worsens contact your doctor immediately. Other symptoms of overdosage might include vomiting, stomach pain with muscle cramps, feeling generally unwell with severe tiredness and difficulty in breathing.

SYNOPSIS

MORE INFORMATION

FAQs ABOUT DEBISTAL GM 2 TABLET

Q: What is DEBISTAL GM 2 TABLET used for?

A: DEBISTAL GM 2 TABLET is an antidiabetic medicine used to manage type II diabetes mellitus when diet, exercise and management with single agent does not result in adequate response.

Q: How and when to take DEBISTAL GM 2 TABLET?

A: Take DEBISTAL GM 2 TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: How long should I take DEBISTAL GM 2 TABLET?

A: You need to take DEBISTAL GM 2 TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: What is the best time to take DEBISTAL GM 2 TABLET?

A: DEBISTAL GM 2 TABLET must be taken with meals to avoid gastrointestinal side effects.

Q: What to do if I forgot to take a dose of DEBISTAL GM 2 TABLET?

A: If you forgot to take a dose of DEBISTAL GM 2 TABLET, take it as soon as you remember. However, if it is time for the next dose of DEBISTAL GM 2 TABLET, skip the missed dose and take the next one regularly.

Q: Can I stop taking DEBISTAL GM 2 TABLET without consulting your doctor?

A: No. You should not stop taking DEBISTAL GM 2 TABLET without consulting your doctor because it may lead to reversal of symptoms.  

Q: Will taking a higher dose of DEBISTAL GM 2 TABLET be more effective?

A: No, taking a higher dose of DEBISTAL GM 2 TABLET will not be effective, rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

Q: Can I take medication for high blood pressure along with DEBISTAL GM 2 TABLET?

A: It is not advisable to take medicines to control blood pressure while taking DEBISTAL GM 2 TABLET without consulting your doctor, as they have known interactions with DEBISTAL GM 2 TABLET.

Q: How to manage the side effects of DEBISTAL GM 2 TABLET?

A: Low blood sugar is a common side effect of taking DEBISTAL GM 2 TABLET. Try to have sugar rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey or sugary candy. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack, or drink, and check the blood sugar levels once again. If your condition did not improve, consult your doctor immediately.