ANJANI MEDICAL
DAPAVEL TRIO 500 Tablet 10's
DAPAVEL TRIO 500 Tablet 10's
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INTRODUCTION ABOUT DAPAVEL TRIO 500 TABLET
DAPAVEL TRIO 500 TABLET is a combination of Dapagliflozin, Metformin, and Sitagliptin, which belongs to the group of medicines called Antidiabetics. It is indicated as an adjunct to diet and exercise to manage glycemic control in adults with type 2 diabetes mellitus.
Prior to the management, your doctor may want you to take several blood tests to understand your existing kidney condition.
DAPAVEL TRIO 500 TABLET is not recommended for use during pregnancy or in breastfeeding women. Consult your doctor before taking it.
DAPAVEL TRIO 500 TABLET is not recommended for use if you have respiratory failure, severe kidney disease, liver disease, heart failure, or a recent myocardial infarction. Consult your doctor before taking it.
The most common side effects of taking DAPAVEL TRIO 500 TABLET are hypoglycemia (low blood glucose level), nausea, vomiting, headache, flatulence, genital infections, and increased or more frequent urination. Consult your doctor if any of the side effects worsen.
USES OF DAPAVEL TRIO 500 TABLET
- Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
HOW DAPAVEL TRIO 500 TABLET WORKS
DAPAVEL TRIO 500 TABLET is a combination of dapagliflozin, metformin, and sitagliptin. Dapagliflozin works by inhibiting the reabsorption of glucose in the kidneys, increasing urinary glucose excretion, and reducing blood glucose levels. Metformin decreases the amount of glucose you absorb from your food and the amount of glucose made by the liver. It also increases the body's response to insulin, a natural substance that controls the amount of glucose in the blood. Sitagliptin helps control blood sugar levels by increasing substances (incretins) in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood.
DIRECTIONS FOR USE
Take DAPAVEL TRIO 500 TABLET as advised by your physician. Swallow this medicine whole with a glass of water, and do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition. Do not stop taking this medicine without consulting your doctor. Otherwise, your blood sugar will rise again.
SIDE EFFECTS OF DAPAVEL TRIO 500 TABLET
COMMON
- Hypoglycemia (low blood glucose level)
- Nausea, vomiting
- Headache
- Flatulence
- Genital infections
- Increased or more frequent urination
UNCOMMON
- Drowsiness, dizziness
- Diarrhea, constipation
- Stomach pain
- Itching
- Dry mouth
- Decreased weight
- Thirst
Stop taking DAPAVEL TRIO 500 TABLET and consult your doctor immediately if you experience any of the following side effects:
- Symptoms of acute pancreatitis, such as severe and persistent abdominal pain that might reach through your back with or without nausea and vomiting
- Symptoms of allergic reactions such as rash, hives, blisters on the skin or peeling skin, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing
- Signs of bullous pemphigoid, such as blistering of the skin
- Symptoms of lactic acidosis include vomiting, abdominal pain, muscle cramps, a general feeling of not being well, severe tiredness, difficulty breathing, reduced body temperature, and a slow heartbeat
- The symptoms of diabetic ketoacidosis are nausea, vomiting, stomach pain, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to your breath, a sweet or metallic taste in your mouth, or a different odour to your urine or sweat, or rapid weight loss
- Symptoms of necrotizing fasciitis of the perineum or Fournier’s gangrene include pain, tenderness, redness, or swelling of the genitals or the area between the genitals and the anus with fever or feeling generally unwell
- Signs of severe infections of the urinary tract include fever, chills, a burning sensation during urination, pain in your back or side, and blood in your urine
HOW TO MANAGE SIDE EFFECTS
Bloating
Eat smaller and more frequent meals. Eat and drink slowly, and exercise regularly. If the flatulence does not improve, contact your doctor.
Constipation
Include fiber-rich foods in your diet, such as fresh fruits, vegetables, and whole-grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Contact your doctor if constipation persists.
Diarrhea
Drink lots of fluids, such as water or fruit juices, to keep yourself hydrated. Do not take any medicine on your own to manage diarrhea. Contact your doctor if your diarrhea does not improve.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive amounts of alcohol. Consult your doctor if your dizziness worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids, such as water or electrolytes. Applying a pain-relieving balm to your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Nausea And Vomiting
Take DAPAVEL TRIO 500 TABLET with a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if your nausea and vomiting do not improve.
Stomach Pain
Rest and relax. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heating pad on your stomach. Do not self-manage on your own; consult your doctor if the stomach pain does not improve on its own.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedDAPAVEL TRIO 500 TABLET is not recommended for use during pregnancy. Consult your doctor before taking it.
BREASTFEEDING
ContraindicatedDAPAVEL TRIO 500 TABLET is not recommended for use by breastfeeding women. Consult your doctor before taking it.
DRIVING AND USING MACHINES
ContraindicatedDo not drive or operate any machines if you have dizziness and drowsiness after taking DAPAVEL TRIO 500 TABLET.
ALCOHOL
ContraindicatedAvoid consumption of alcohol while taking DAPAVEL TRIO 500 TABLET, as it may increase the risk of lactic acidosis.
KIDNEY
Consult your doctorDAPAVEL TRIO 500 TABLET is not recommended for use in patients with severe kidney disease. It should be used with caution in patients with mild to moderate kidney disease. Consult your doctor before taking it.
LIVER
ContraindicatedDAPAVEL TRIO 500 TABLET is not recommended for use if you have liver disease. Consult your doctor before taking it.
ALLERGY
ContraindicatedDAPAVEL TRIO 500 TABLET is not recommended for use if you are allergic to dapagliflozin, metformin, sitagliptin, or any of the other ingredients of this medicine.
LUNGS
ContraindicatedDAPAVEL TRIO 500 TABLET is not recommended for use if you have respiratory failure. Consult your doctor before taking it.
HEART DISEASE
ContraindicatedDAPAVEL TRIO 500 TABLET is not recommended for use if you have heart failure or a recent myocardial infarction. Consult your doctor before taking it.
USE IN PEDIATRICS
ContraindicatedDAPAVEL TRIO 500 TABLET is not recommended for use in children and adolescents below 18 years of age as safety and efficacy are not clinically established. Contact your doctor before taking.
USE IN GERIATRICS
Use with CautionDAPAVEL TRIO 500 TABLET should be used with caution in elderly patients (aged 65 years or older). Contact your doctor before taking.
OTHERS
DAPAVEL TRIO 500 TABLET is not recommended for use if you:
- Have Type 1 diabetes mellitus
- Have acute metabolic acidosis (such as lactic acidosis or diabetic ketoacidosis)
- Have diabetic pre-coma
- Have dehydration
- Have a severe infection
- Have shock
- Are scheduled for a lab test
- Are planned for surgery
Before taking DAPAVEL TRIO 500 TABLET, inform your doctor if you:
- Have a history of pancreatitis
- Have or have had gallstones
- Have very high levels of triglycerides (a form of fat) in your blood
INTERACTIONS
A. Drug-Drug interactions:
Before taking DAPAVEL TRIO 500 TABLET, inform your doctor if you are taking prescription, non-prescription, or herbal supplements.
- Sulphonylureas or with insulin (other medicines used to manage diabetes mellitus) Ex. glimepiride
- Ketoconazole and itraconazole (medicines used to manage fungal infections)
- Ritonavir (a medicine used to manage viral infections)
- Clarithromycin (a medicine used to manage bacterial infections)
- Corticosteroids (medicines used to manage pain and inflammatory conditions) like asthma and arthritis Ex. dexamethasone
- Medicines that increase urine production (diuretics) Ex. furosemide
- Medicines used to manage pain and inflammation (NSAIDs and COX-2-inhibitors, such as ibuprofen and celecoxib)
- Medicines for the management of high blood pressure (ACE inhibitors and angiotensin II receptor antagonists) Ex. enalapril, losartan
- Sympathomimetics (medicines used in the management of asthma) Ex. salbutamol
- Iodinated contrast agents or alcohol-containing medicines
- Medicines used to manage stomach problems, such as cimetidine
- Ranolazine, a medicine used to manage angina
- Dolutegravir, a medicine used to manage HIV infection
- Vandetanib, a medicine used to manage a specific type of thyroid cancer
- Digoxin (to manage irregular heartbeats and other heart problems)
Overdosage:
If you or anyone else accidentally took too much of this medicine, consult your doctor immediately. The symptoms of an overdose include hypoglycemia. Overdosage may cause lactic acidosis, and symptoms include feeling cold or uncomfortable, severe nausea or vomiting, stomach pain, unexplained weight loss, muscular cramps, or rapid breathing.
SYNOPSIS
| Drug | : | Dapagliflozin, Metformin, and Sitagliptin |
| Pharmacological Category | : | Antidiabetics |
| Therapeutic Indication | : | Type 2 diabetes mellitus |
| Dosage Forms | : | Tablet |
MORE INFORMATION
STORAGE
- Keep DAPAVEL TRIO 500 TABLET out of reach of children
- Store at room temperature
FAQs ABOUT DAPAVEL TRIO 500 TABLET
Q: What is DAPAVEL TRIO 500 TABLET used for?
A: It is used to manage type 2 diabetes mellitus along with diet and exercise when diabetes cannot be controlled with other medicines.
Q: Who should not take DAPAVEL TRIO 500 TABLET?
A: DAPAVEL TRIO 500 TABLET is not recommended for use if you have respiratory failure, severe kidney disease, liver disease, heart failure, recent myocardial infarction, Type 1 diabetes mellitus, acute metabolic acidosis (such as lactic acidosis and diabetic ketoacidosis), diabetic pre-coma, dehydration, severe infection, or shock. Consult your doctor before taking it.
Q: Can I take alcohol while using DAPAVEL TRIO 500 TABLET?
A: No. Avoid consumption of alcohol while taking DAPAVEL TRIO 500 TABLET, as it may increase the risk of lactic acidosis.
Q: Is DAPAVEL TRIO 500 TABLET safe for kidneys?
A: DAPAVEL TRIO 500 TABLET is not recommended for use in patients with severe kidney disease. It should be used with caution in patients with mild to moderate kidney disease. Consult your doctor before taking it.
Q: How does DAPAVEL TRIO 500 TABLET work?
A: DAPAVEL TRIO 500 TABLET is a combination of dapagliflozin, metformin, and sitagliptin. Dapagliflozin increases urinary glucose excretion and reduces blood glucose levels. Metformin decreases the amount of glucose you absorb from your food and the amount of glucose made by the liver. It also increases the body's response to insulin, a natural substance that controls the amount of glucose in the blood. Sitagliptin helps control blood sugar levels by increasing substances (incretins) in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood.
Q: Can I use DAPAVEL TRIO 500 TABLET with other diabetic medications?
A: Your doctor may advise DAPAVEL TRIO 500 TABLET with or without other medications to control your blood sugar levels. However, it is advised to maintain a proper diet and exercise to achieve controlled blood sugar levels while using this medicine with or without other antidiabetic medications.
Q: Can DAPAVEL TRIO 500 TABLET be used during pregnancy?
A: DAPAVEL TRIO 500 TABLET is not recommended for use during pregnancy. Consult your doctor before taking it.
Q: Does DAPAVEL TRIO 500 TABLET cause low blood sugar?
A: Yes. DAPAVEL TRIO 500 TABLET may cause low blood sugar. Stop taking DAPAVEL TRIO 500 TABLET and contact your doctor if you experience any unusual symptoms like weakness, shaking, sweating, drowsiness, dizziness, feeling very anxious, fast heartbeat, hunger, headache, change in vision, change in mood or confusion, and irritability.
Q: Is DAPAVEL TRIO 500 TABLET safe for kids?
A: DAPAVEL TRIO 500 TABLET is not recommended for use in children and adolescents below 18 years of age as safety and efficacy are not clinically established. Contact your doctor before taking.
Q: What are the side effects of DAPAVEL TRIO 500 TABLET?
A: The most common side effects of taking DAPAVEL TRIO 500 TABLET are hypoglycemia (low blood glucose level), nausea, vomiting, headache, flatulence, genital infections, and increased or more frequent urination. Consult your doctor if any of the side effects worsen.
